Melita B. Irving

This paper describes LimCORE, an automated system for CAR-T cell manufacturing that achieves comparable performance to existing methods while reducing operator time.

This study investigates how therapeutic CD8+ T cells interact with myeloid cells in the tumor microenvironment through antigen recognition, revealing state-selective networks and the role of pMHC-I sources.

This paper develops DROP-CARs, drug-regulated CAR-T cells that control cell-cell interactions using small-molecule switches, showing in vitro and in vivo functionality.

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.

This study shows that PI-103 and samotolisib enhance CRISPR/Cas9-mediated TCR knockin efficiency in human T cells without affecting viability or phenotype.

This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.