Non-fibrillar prion protein oligomers transmit structural information during early assembly
Stéphanie Prigent, Ariane Deniset‐Besseau, Jérémie Mathurin, Angélique Igel‐Egalon, Hannah Klute, Jan Bohl, Guillaume van der Rest, Christian Malosse, Sophie Lecomte, Hadi Rezaei, Joan Torrent, Vincent Béringue, Alexandre Dazzi, Davy Martin, Human Rezaei
This study shows non-fibrillar prion protein oligomers can transmit folding information during early assembly, challenging the classical fibril-end templating model.
bioRxiv · Mar 27, 2026 · PreprintBiochemistry