Angélique Igel‐Egalon

This study shows non-fibrillar prion protein oligomers can transmit folding information during early assembly, challenging the classical fibril-end templating model.

This paper develops a stochastic reaction-diffusion model to study prion spreading dynamics, showing how non-linear tissue responses and replication kinetics interact to explain strain-specific phenotypes and neuro-invasion.

The paper compares two prion growth models, showing that the detailed balance between PrPSc and suPrP can replace the induced-fragmentation model.

The paper shows that structurally diverse PrPSc assemblies complement each other to cross species barriers, supporting the quasi-species concept in prions.