Pseudomonas aeruginosa biofilm-deficient mutants undergo parallel adaptation during chronic infection
Erin S. Gloag, Christopher W. Marshall, Nanami Kubota, Stacie E. Deaver, Brennan Deshotel, Vaughn S. Cooper, Daniel J. Wozniak
This study identifies genetic adaptations in Pseudomonas aeruginosa during chronic infection that lead to hyperbiofilm phenotypes through mutations in lipopolysaccharide and type IV pili biosynthesis.
bioRxiv · Sep 20, 2025 · PreprintMicrobiology