Rescuing Photoreceptors in RPE Dysfunction-Driven Retinal Degeneration: The Role of Small Extracellular Vesicles Secreted from Retinal Pigment Epithelium
Dimitrios Pollalis, Constantin Georgescu, Jonathan D. Wren, Grigor Tombulyan, Justin Leung, Pein-An Lo, Clarisa Marie Bloemhof, Ryang Hwa Lee, Eun‐Hye Bae, Jeff Bailey, Britney O. Pennington, Amir I. Khan, Kaitlin R. Kelly, Ashley K. Yeh, Kartik S. Sundaram, , Sun Young Lee
This study investigates the therapeutic potential of RPE-secreted small extracellular vesicles in rescuing photoreceptors in retinal degeneration, showing gene expression reversal and functional improvement in a rat model.
bioRxiv · Apr 9, 2024 · PreprintNeuroscience