Jonathan D. Wren

Tetraspanin changes in septic blood are organized by cell type, with monocyte CD82 induction and leukocyte CD37 loss associated with mortality

The paper identifies cell-type-specific tetraspanin changes in sepsis, finding CD37 loss and monocyte CD82 induction linked to mortality.

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

Methylation Array Signals are Predictive of Chronological Age Without Bisulfite Conversion

The paper shows that non-methylation factors cause age-predictive pseudomethylation signals in methylation arrays, affecting epigenetic clocks.

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Maturation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium

This study profiles miRNA in extracellular vesicles secreted during the maturation of human embryonic stem cell-derived RPE cells to inform EV-based therapeutics.

AutoGDC: A Python Package for DNA Methylation and Transcription Meta-Analyses

AutoGDC provides a Python package for streamlined DNA methylation and RNA sequencing meta-analyses using data from the Genomic Data Commons.

Rescuing Photoreceptors in RPE Dysfunction-Driven Retinal Degeneration: The Role of Small Extracellular Vesicles Secreted from Retinal Pigment Epithelium

This study investigates the therapeutic potential of RPE-secreted small extracellular vesicles in rescuing photoreceptors in retinal degeneration, showing gene expression reversal and functional improvement in a rat model.

Persistent homology centrality improves link prediction performance in PubMed co-occurrence networks

This paper introduces a method using persistent homology to predict links in PubMed co-occurrence networks by analyzing the dynamic structure of scientific literature.

Calorie Restriction Prevents Age-Related Changes in the Intestinal Microbiota

This study shows that calorie restriction in mice increases microbial diversity and prevents age-related microbiome changes, maintaining a younger microbial and metabolite profile.

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells

This study shows that cigarette smoke activates NOTCH3, promoting goblet cell differentiation in human airway epithelial cells, contributing to COPD-related goblet cell metaplasia.

Sexually divergent DNA methylation programs with hippocampal aging

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.