Constantin Georgescu

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

This study uses a baboon model of sepsis to analyze cardiomyopathy through multimodal techniques, finding distinct transcriptomic and physiological differences between survivors and non-survivors.

This study profiles miRNA in extracellular vesicles secreted during the maturation of human embryonic stem cell-derived RPE cells to inform EV-based therapeutics.

This study investigates the therapeutic potential of RPE-secreted small extracellular vesicles in rescuing photoreceptors in retinal degeneration, showing gene expression reversal and functional improvement in a rat model.

This study shows that cigarette smoke activates NOTCH3, promoting goblet cell differentiation in human airway epithelial cells, contributing to COPD-related goblet cell metaplasia.

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.