Pathogenic variants of the mitochondrial copper chaperones SCO1 and SCO2 reshape their respective interactomes and disrupt cellular phospholipid metabolism
Sampurna Ghosh, Zakery N. Baker, Rachel M. Guerra, Hana Antonická, Abhinav B. Swaminathan, Vishal M. Gohil, David J. Pagliarini, Stanley A. Moore, Scot C. Leary
This study maps the interactomes of pathogenic SCO1 and SCO2 variants using BioID, revealing their roles in copper delivery and phospholipid metabolism disruption.
bioRxiv · Sep 24, 2026 · PreprintMolecular Biology