Rachel M. Guerra

Pathogenic variants of the mitochondrial copper chaperones SCO1 and SCO2 reshape their respective interactomes and disrupt cellular phospholipid metabolism

This study maps the interactomes of pathogenic SCO1 and SCO2 variants using BioID, revealing their roles in copper delivery and phospholipid metabolism disruption.

RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis

This study shows RTN4IP1 is critical for mitochondrial complex I assembly and coenzyme Q biosynthesis, with mutations causing defects in both processes in patient cells.

Fmp30 is a phosphatidylinositol hydrolase that regulates CoQ biosynthesis

The paper identifies Fmp30 as a phosphatidylinositol hydrolase that negatively regulates CoQ biosynthesis in yeast by affecting lipid metabolism.

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis

The paper identifies genes and metabolic regulators of nucleotide synthesis using uridine salvage and CRISPR-Cas9 screening, revealing NUDT5's role in maintaining nucleotide balance and its impact on chemotherapy resistance.