In vivo validation of predicted fitness effects at single-base resolution in a Brachypodium distachyon mutant population
Camous Moslemi, Marine Folgoas, Xiaqing Yu, Julie D. Jensen, Stephan Hentrup, Tianyi Li, Hai Wang, Birte Boelt, T Asp, Richard Sibout, Guillaume P. Ramstein
The paper validates variant effect predictions in a Brachypodium distachyon mutant population using burden and purging tests, showing ESM outperforms SIFT and PlantCAD for missense variants.
bioRxiv · Apr 2, 2026 · PreprintGenomics