In vivo validation of predicted fitness effects at single-base resolution in a Brachypodium distachyon mutant population
Camous Moslemi, Marine Folgoas, Xiaqing Yu…·Guillaume P. Ramstein
The paper validates variant effect predictions in a Brachypodium distachyon mutant population using burden and purging tests, showing ESM outperforms SIFT and PlantCAD for missense variants.