Hao Wang

This study identifies a tumor-pituitary-stromal signaling axis that promotes colorectal cancer progression by enhancing pituitary growth hormone output and fibroblast-mediated tumor promotion.

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

This study identifies HSD11B1 as a direct target of magnesium isoglycyrrhizinate, revealing its therapeutic mechanism in alcohol-associated liver disease through the HSD11B1-SREBP2-IDI1 signaling axis.

IEKB is a database that integrates curated gene-phenotype-disease associations, cochlear gene interactions, and a scientific network for inner-ear genetics research.

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

This study shows that microhomology-mediated end joining (MMEJ) repairs single-ended DSBs at replication forks, working with BIR and being regulated by ATR and Pol{theta}.

The paper develops deep learning models to predict gene expression across species and assesses their ability to capture regulatory variant effects in Brachypodium mutant lines, showing improved accuracy over existing methods.

This study shows that pathogenic missense mutations affect Menin function through dynamic changes and allostery, not just structural destabilization.

This study shows that transplanting ANXA1-negative CD8 naive T cells extends lifespan and improves health in aged mice by reducing senescence.

This study reconstructs the evolutionary history of Coilia species, revealing ancient reciprocal introgression and its role in adaptation to geoclimatic changes.

This paper introduces a 3D synthetic platform to study cancer cell invasion and drug response by modeling mechanical interactions with the extracellular matrix.

The study shows that non-coding Pink1 mRNA regulates mitochondria homeostasis by interacting with YME1L1 to modulate Opa1 processing, independent of its coding function.

This paper develops a framework to evaluate fluorescence trace quality for transcription kinetics by identifying thresholds for signal-to-noise ratio and trace length using synthetic data.

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.