Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes towards a Purkinje Fiber Fate
David M. Gonzalez, Rafael Dariolli, Julia Moyett, Stephanie Song, Bhavana Shewale, Jacqueline M. Bliley, Daniel J. B. Clarke, Avi Ma’ayan, Stacey Rentschler, Adam W. Feinberg, Eric A. Sobie, Nicole C. Dubois
The paper shows that transient Notch activation converts human pluripotent stem cell-derived cardiomyocytes into Purkinje fiber-like cells with altered electrophysiology and gene expression.
bioRxiv · Sep 22, 2024 · PreprintDevelopmental Biology