Nicole C. Dubois

The paper shows that transient Notch activation converts human pluripotent stem cell-derived cardiomyocytes into Purkinje fiber-like cells with altered electrophysiology and gene expression.

The paper identifies cardiotoxic drug signatures using bulk transcriptomics and integrates them with genomic and single-cell data to predict toxicity mechanisms.

The paper identifies the Foxa2 lineage's role in lung development and demonstrates that conditional complementation of this lineage can generate a whole lung in mice.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study identifies and characterizes hPSC-derived FOXA2+ progenitor cells with enhanced ventricular cardiomyocyte differentiation potential.

The paper uses single-cell RNA sequencing to study atrial and ventricular myocardial cell differentiation, identifying lineage trajectories and effects of retinoic acid on cardiac development.

The paper identifies Notch signaling's role in cardiac mesoderm specification, showing it enhances cardiomyocyte differentiation while maintaining an immature state in human pluripotent stem cells.