Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays
Stanley I. Goldstein, Alice C. Fan, Zihao Wang, Sai Kiran Naineni, Regina Cencic, Steve B. Garcia-Gutierrez, Kesha Patel, Sidong Huang, Lauren E. Brown, Andrew Emili, John A. Jr. Porco
The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.
Journal of Proteome Research · Mar 13, 2025Peer-reviewedBiochemistry