Sidong Huang

This study identifies a synergistic therapeutic effect of combining MNK1/2 inhibition with G1/S CDK blockade in triple-negative breast cancer.

This study identifies ATR and PKMYT1 as targets to overcome carboplatin resistance in TNBC by re-sensitizing resistant models to carboplatin through mitotic catastrophe.

This study shows that inhibiting MYSM1's deubiquitinase activity protects against MYC-driven B cell lymphoma through both tumor intrinsic effects and modulation of antitumor immunity.

The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.

This study shows that TSC2 loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts, which can be reversed by inhibiting mTORC1 or MNK1/2.

The paper investigates the evolution of chromosome 4p loss in basal breast cancer, identifying C4orf19 as a novel gene that suppresses proliferation and is part of a kinase module.