ImmunologybioRxivPreprint
Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
Simon Schuster, Frederike A. Hartl, Jennifer Stehle…·Jörg Birkenfeld
This paper introduces ValidaTe, a framework to predict and mitigate off-target liabilities in TCR-mimic antibodies, demonstrating its effectiveness with CTA MAGE-A4 targets.
DOI 10.64898/2026.07.30.741432