Author

Frederike A. Hartl

University of FreiburgORCID 0000-0003-3538-5214Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander Sinclair· 1 shared Anna-Maria SchafferiD· 1 shared Azin Kiani· 1 shared Badeel Kh Q ZaghlaiD· 1 shared Benedetta Leoni· 1 shared Bilge AtayiD· 1 shared Bjoern Steinmann· 1 shared Cabrera MaiaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alexander Sinclair

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 4, 2026

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework

Simon Schuster, Frederike A. Hartl, Jennifer Stehle…·Jörg Birkenfeld

This paper introduces ValidaTe, a framework to predict and mitigate off-target liabilities in TCR-mimic antibodies, demonstrating its effectiveness with CTA MAGE-A4 targets.

DOI 10.64898/2026.07.30.741432

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 12, 2025

Controlling TCR and CAR activation by targeting LCK recruitment with a first-in-class small-molecule inhibitor

Nadine M. Woessner, Patricio Chinestrad, Tamina Rückert…·Susana Minguet

This study identifies a small-molecule inhibitor that selectively disrupts LCK recruitment to CD3ε, reducing TCR activation while preserving other immune responses.

1 citation

humanproteomics

𝕏 PostBluesky