Sensory neuron fate is developmentally perturbed by Gars mutations causing human neuropathy
James N Sleigh, John M Dawes, Steven J West, Emily L Spaulding, Adriana Gomez-Martin, Robert W Burgess, M. Zameel Cader, Kevin Talbot, David L Bennett, Giampietro Schiavo
This study shows Gars mutations disrupt sensory neuron subtype balance in CMT2D mice, causing sensory defects and indicating both developmental and degenerative mechanisms contribute to the disease.
Proceedings of the National Academy of Sciences · Mar 28, 2017Peer-reviewedNeuroscience