Kevin Talbot

This study identifies uORF elements regulating BDNF translation and demonstrates that disrupting uORFs can upregulate BDNF expression in cell culture.

This study shows that the TDP-43M337V mutation in microglia alters miRNA release in a sex-specific way, potentially affecting ALS progression.

This study uses a Network Diffusion Model to show that structural brain networks drive pathological spread in ALS, with seed regions in basal ganglia, thalamus, and insula, not the primary motor cortex.

This study corrects a C9orf72 hexanucleotide expansion in iPSC-derived motor neurons using CRISPR/Cas9 and HDR, restoring normal gene expression and eliminating pathological phenotypes.

The paper examines axonal transport defects in two ALS mouse models, finding that TDP-43 mutations cause transport issues while FUS mutations do not.

This study shows Gars mutations disrupt sensory neuron subtype balance in CMT2D mice, causing sensory defects and indicating both developmental and degenerative mechanisms contribute to the disease.