Molecular BiologybioRxivPreprint
Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia
Maria Ibrahim, Maria Gomez-Jenkins, Adina Scheinfeld…·Eileen White
This paper shows autophagy prevents cachexia by suppressing CCL2, which damages appetite-promoting neurons, leading to lethal weight loss in mice.
DOI 10.1101/2025.02.20.638910