Maria Ibrahim

This study shows that caloric restriction before tumor induction delays cancer cachexia by reducing systemic inflammation and preserving lean mass.

The paper identifies altered tryptophan metabolism in cancer cachexia, showing serotonin depletion and kynurenine accumulation, which drive behavioral dysfunction but not wasting.

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

This study investigates the effect of dietary fiber on immune checkpoint blockade efficacy in murine tumor models and finds inconsistent results across different models.

This paper shows autophagy prevents cachexia by suppressing CCL2, which damages appetite-promoting neurons, leading to lethal weight loss in mice.

This study investigates the role of intestinal ESRRA in diet-induced obesity using mouse genetics and genomics, finding that ESRRA's effect is independent of intestinal function.