Circular RNAs accumulate in ageing human placental tissue and in stillbirth, leading to DNA damage and cellular senescence
Anya L. Arthurs, Matilda R. Jackson, Dylan McCullough, Hamish S. Scott, Christopher Barnett, Stuart T. Webb, M. Smith, Tanja Jankovic‐Karasoulos, Gustaaf Dekker, Claire Trelford Roberts
This study shows that circular RNAs accumulate in aged human placental tissue and in stillbirth cases, causing DNA damage and cellular senescence, and suggests they could be used for stillbirth risk screening.
American Journal of Obstetrics and Gynecology · Aug 29, 2025Peer-reviewedMolecular Biology