M. Smith

This study identifies oxidative stress and TERRA loss as drivers of placental aging in late-onset preeclampsia, showing antioxidant treatment can mitigate these effects.

This study shows that circular RNAs accumulate in aged human placental tissue and in stillbirth cases, causing DNA damage and cellular senescence, and suggests they could be used for stillbirth risk screening.

This study uses gene-edited placental organoids to show that ACE2 knockout causes delayed growth and increased cell death, while the ACE2 rs2074192 TT genotype increases ACE2 expression but reduces enzyme activity.

This paper identifies a 20-miRNA signature to detect haemolysis in microRNA-seq data from clinical plasma samples.

DraculR detects haemolysis contamination in small RNA sequencing data by calculating a haemolysis metric from microRNA expression data.