Claire Trelford Roberts

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsia

This paper develops a genetically engineered trophoblast organoid model of preeclampsia that recapitulates molecular and functional features of the disease.

Genetic Variants Associated with Placental Abnormalities in Stillbirths

The paper identifies genetic variants associated with placental abnormalities in stillbirths by analyzing exome sequencing data from placental and fetal samples.

Late-Onset Preeclampsia is characterised by Accelerated Placental Aging

This study identifies oxidative stress and TERRA loss as drivers of placental aging in late-onset preeclampsia, showing antioxidant treatment can mitigate these effects.

Circular RNAs accumulate in ageing human placental tissue and in stillbirth, leading to DNA damage and cellular senescence

This study shows that circular RNAs accumulate in aged human placental tissue and in stillbirth cases, causing DNA damage and cellular senescence, and suggests they could be used for stillbirth risk screening.

Genetically edited human placental organoids cast new light on the role of ACE2 in placental development

This study uses gene-edited placental organoids to show that ACE2 knockout causes delayed growth and increased cell death, while the ACE2 rs2074192 TT genotype increases ACE2 expression but reduces enzyme activity.

Haemolysis detection in microRNA-seq from clinical plasma samples

This paper identifies a 20-miRNA signature to detect haemolysis in microRNA-seq data from clinical plasma samples.

DraculR: A web based application for in silico haemolysis detection in high throughput small RNA sequencing data

DraculR detects haemolysis contamination in small RNA sequencing data by calculating a haemolysis metric from microRNA expression data.