TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression
Hannah Hillman, Gage M Stuttgen, Su-Jeong Lee, Michael T Patterson, Michael D Chang, Yingyue Zhou, Ainsley E Kennedy, Patricia R Schrank, Omer Mitha, Tessa J Barrett, Marco Colonna, Jesse W Williams
This study identifies TREM2's role in atherosclerosis regression by enhancing efferocytosis in lipid-experienced macrophages, suggesting TREM2 as a therapeutic target for plaque stabilization.
bioRxiv · Nov 2, 2026 · PreprintImmunology