Dynamic changes in oligomeric complexes of UPR sensors induced by misfolded proteins in the ER
Arunkumar Sundaram, Suhila Appathurai, Malaiyalam Mariappan
This study examines how misfolded proteins affect the oligomerization and activation of UPR sensors in ER stress, finding that misfolded proteins directly activate preformed oligomers rather than through BiP release.
bioRxiv · Sep 15, 2017 · PreprintCell Biology