Engineering circular guide RNA and CRISPR-Cas13d-encoding mRNA for the RNA editing of Adar1 in triple-negative breast cancer immunotherapy
Shurong Zhou, Suling Yang, Jie Xu, Guizhi Zhu
This study develops circular guide RNAs (cgRNAs) and Cas13d-encoding mRNA for efficient RNA editing of Adar1 in triple-negative breast cancer, showing improved stability and therapeutic efficacy.
bioRxiv · Jul 22, 2025 · PreprintBioengineering