Isolation of Pure Disease Specific Aging Trajectories in Spatial Transcriptomics via the Delta Delta Method
Moonseok Choi, Sungsu Hwang, Kyu‐Sung Kim, Jin‐Ho Choi, Kyemyung Park, Do-Geun Kim
The paper introduces the Delta-Delta Method to isolate disease-specific aging trajectories in spatial transcriptomics by subtracting wild-type aging from transgenic trajectories, revealing distinct molecular programs in neurodegeneration.
bioRxiv · Oct 1, 2025 · PreprintBioinformatics