Moonseok Choi

Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimers Disease

This paper investigates CSF flow failure in Alzheimer's disease by showing structural collapse in perivascular spaces and impaired cholesterol clearance leading to fluid stagnation.

Divergent transcriptomic transition programs in Alzheimer disease: immune priming and synaptic collapse in females versus organelle membrane bifurcation in males

The paper identifies divergent transcriptomic transition programs in Alzheimer's disease between females and males, showing distinct molecular pathways in disease progression.

Transcriptomic phase transitions along the Alzheimer's disease continuum using riemmaninan tensor model: a bifurcation-intermediate variance framework on the ROSMAP cohort

The paper uses Riemannian geometry on bulk RNA-seq data from the ROSMAP cohort to analyze transcriptomic changes across Alzheimer's disease stages, identifying MCI as a bifurcation state.

Riemannian Tensor Analysis Identifies a Bifurcation State in the Single-Cell Transcriptomic Landscape of Parkinson's Disease

This paper identifies a bifurcation state in Parkinson's disease transcriptomics using a Riemannian tensor framework, showing it as a geometric saddle point between healthy and diseased states.

Isolation of Pure Disease Specific Aging Trajectories in Spatial Transcriptomics via the Delta Delta Method

The paper introduces the Delta-Delta Method to isolate disease-specific aging trajectories in spatial transcriptomics by subtracting wild-type aging from transgenic trajectories, revealing distinct molecular programs in neurodegeneration.