Do-Geun Kim

This paper investigates CSF flow failure in Alzheimer's disease by showing structural collapse in perivascular spaces and impaired cholesterol clearance leading to fluid stagnation.

The paper identifies divergent transcriptomic transition programs in Alzheimer's disease between females and males, showing distinct molecular pathways in disease progression.

The paper uses Riemannian geometry on bulk RNA-seq data from the ROSMAP cohort to analyze transcriptomic changes across Alzheimer's disease stages, identifying MCI as a bifurcation state.

This paper identifies a bifurcation state in Parkinson's disease transcriptomics using a Riemannian tensor framework, showing it as a geometric saddle point between healthy and diseased states.

The paper introduces the Delta-Delta Method to isolate disease-specific aging trajectories in spatial transcriptomics by subtracting wild-type aging from transgenic trajectories, revealing distinct molecular programs in neurodegeneration.

This study shows that Influenza A virus infection causes neuronal damage and TDP-43 pathology in mice brains without persistent viral protein expression.