Regulatory architecture of the RCA gene cluster captures an intragenic TAD boundary, CTCF-mediated chromatin looping and a long-range intergenic enhancer
Jessica Cheng, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Rhonda L. Taylor, Sündüz Keleş, Martin Franke, Susan A. Boackle, John B. Harley, Elizabeth A. Quail, José Luis Gómez-Skármeta, Daniela Ulgiati
The paper identifies regulatory elements and chromatin structures in the RCA gene cluster, revealing long-range interactions and a TAD boundary within CR1 that influence gene expression and autoimmune disease susceptibility.
Frontiers in Immunology · Jun 13, 2022Peer-reviewedGenetics