Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy
Nadiia Lypova, Susan M. Dougherty, Brian F. Clem, Jing Chun Feng, Xinmin Yin, Xiang Zhang, Xiaohong Li, Jason Alan Chesney, Yoannis Imbert-Fernandez
This study shows that inhibiting PFKFB3 enhances the effectiveness of EGFR-TKIs by disrupting metabolic adaptations and DNA repair in drug-tolerant lung cancer cells.
Cancer & Metabolism · Dec 18, 2024Peer-reviewedCancer Biology