A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification.
Bau‐Lin Huang, Sean R. Davis, Eiki Koyama, Maurizio Pacifici, Susan Mackem
The paper shows that Wnt antagonists, working with Fgfs, prevent premature pSmad1/5 accumulation to maintain mesenchymal plasticity and balance digit phalanx and joint formation.
bioRxiv · Jul 17, 2025 · PreprintDevelopmental Biology