Susan Mackem

This study identifies dual Bmp-negative feedback loops that regulate AER and ZPA function to constrain postaxial digit number to the pentadactyl state in vertebrates.

This study shows that reducing endogenous Myc levels in p53-deficient mice extends tumor-free survival and that tumors compensate by increasing Myc dosage or expression.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

This study shows Sonic Hedgehog (Shh) acts as a trigger for digit specification through a relay network rather than as a traditional morphogen.

The paper investigates how mutual repression between Gli3 and Hox13 genes determines the anterior-posterior asymmetry of the autopod, explaining digit 1 agenesis in Hoxa13 mutants.