Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8+ T cells
Benjamin D. S. Clarkson, Susanna Pucci, Ramila Barun Shrestha, Kiran Kumar Mangalaparthi, Remya Raja, Marion Curtis, Akhilesh Pandey, Charles L. Howe
This study identifies IFNγ-induced HLA class I-restricted neuronal autoantigens and their recognition by CD8+ T cells using human iPSC-derived neurons and immunopeptidomics.
bioRxiv · May 26, 2026 · PreprintImmunology