Author

Charles L. Howe

Mayo ClinicORCID 0000-0002-3889-8739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Benjamin D. S. ClarksoniD· 2 shared Reghann G. LaFrance‐CoreyiD· 2 shared Akhilesh PandeyiD· 1 shared Brittany L. Overlee· 1 shared Emma N. GodderyiD· 1 shared Fatemeh Khadjevand· 1 shared Gregory A. WorrelliD· 1 shared Kanish MirchiaiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

Benjamin D. S. ClarksonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8+ T cells

Benjamin D. S. Clarkson, Susanna Pucci, Ramila Barun Shrestha, Kiran Kumar Mangalaparthi, Remya Raja, Marion Curtis, Akhilesh Pandey, Charles L. Howe

This study identifies IFNγ-induced HLA class I-restricted neuronal autoantigens and their recognition by CD8+ T cells using human iPSC-derived neurons and immunopeptidomics.

bioRxiv · May 26, 2026 · PreprintImmunology

Characterization of HLA-restricted GAD65-specific CD8+ T cell responses in patients with GAD65 antibody-associated neurological disorders

Pei Shang, Benjamin D. S. Clarkson, Brittany L. Overlee, Charles L. Howe

This study identifies HLA-restricted CD8+ T cell responses to GAD65 peptides in patients with GAD65 antibody-associated neurological disorders, showing cytotoxic activity against GAD65-expressing cells.

bioRxiv · May 22, 2026 · PreprintImmunology

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Charles L. Howe, Reghann G. LaFrance‐Corey, Emma N. Goddery, Renee K. Johnson, Kanish Mirchia

This study identifies neuronal CCL2 expression as critical for recruiting inflammatory monocytes into the brain during acute TMEV infection.

Journal of Neuroinflammation · Dec 1, 2017Peer-reviewedNeuroscience

Systemic evidence of acute seizure-associated neuronal injury in patients with temporal lobe epilepsy

Shailaja Kunda, Reghann G. LaFrance‐Corey, Fatemeh Khadjevand, Gregory A. Worrell, Charles L. Howe

The paper measures serum NSE levels in epilepsy patients and controls to assess neuronal injury post-seizures, finding elevated NSE after seizures and a link between EEG spikes and NSE increases.

bioRxiv · Sep 4, 2017 · PreprintNeuroscience