ALS/FTD-associated TDP-43 mutations promote fragility of genes governing excitatory neurotransmission via topoisomerase IIβ impairment
Harman Sharma, Sushma Koirala, Megan Fowler, Mary‐Louise Rogers, Yee Lian Chew, Anna Konopka
This paper shows that ALS/FTD-linked TDP-43 mutations cause DNA breaks in genes controlling excitatory neurotransmission by impairing topoisomerase IIβ function.
bioRxiv · Dec 10, 2025 · PreprintNeuroscience