OOCYTE AND EMBRYO CULTURE UNDER OIL PROFOUNDLY ALTERS EFFECTIVE CONCENTRATIONS OF SMALL MOLECULE INHIBITORS
Gaudeline Rémillard‐Labrosse, Sydney Cohen, Éliane Boucher, Kéryanne Gagnon, Filip Vasilev, Aleksandar I. Mihajlović, Greg FitzHarris
The paper shows that oil-covered culture systems reduce the effectiveness of small molecule inhibitors in oocyte and embryo experiments, affecting EC50 values and suggesting potential issues with reproducibility.
bioRxiv · Nov 10, 2023 · PreprintDevelopmental Biology