HDAC inhibition via suberoylanilide hydroxamic acid (SAHA) ameliorates Doxorubicin-induced cardiotoxicity
Benay Eksi, Daniel Finke, Synje Michel, Jannek Brauer, Markus B. Heckmann, Mohsen Valadan, Leonard M. Schanze, Vighnesh Sunder, Hugo Albert Katus, Norbert Frey, Johannes Backs, Lorenz Lehmann
This study shows that HDAC inhibition with SAHA reduces doxorubicin-induced cardiotoxicity by modulating Topo IIb and MEF2-dependent transcription.
European Heart Journal Supplements · Aug 1, 2026Peer-reviewedMolecular Biology