The 2-oxoglutarate/malate carrier extends the family of mitochondrial carriers capable of FA-activated proton transport.
K. Zuna, T. Tyschuk, T. Beikbaghban, F. Sternberg, J. Kreiter, E. E. Pohl
This study shows that the mitochondrial 2-oxoglutarate/malate carrier (OGC) mediates FA-activated proton transport, revealing its role in cancer metabolism and potential as a drug target.
bioRxiv · Dec 14, 2023 · PreprintBiophysics