In situ cell-surface conformation of the TCR-CD3 signaling complex
M. Krogsgaard, A. Natarajan, W. Wang, M. B. Flores, T. Li, H. W. Shin, S. Beesam, T. Cardozo
The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.
bioRxiv · Feb 7, 2022 · PreprintImmunology