The role of memory in non-genetic inheritance and its impact on cancer treatment resistance
T. Cassidy, D. Nichol, M. Robertson-Tessi, M. Craig, A. R. A. Anderson
This paper develops a mathematical model of stochastic phenotype switching in cancer cells to show how non-genetic inheritance contributes to treatment resistance and proposes a therapeutic strategy to enhance treatment efficacy.
bioRxiv · Feb 22, 2021Cancer Biology