An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP
T. Cottle, L. Joh, C. Posner, A. DeCosta, J. R. Kardon
The paper identifies POLDIP2 as a heme-sensing adaptor that facilitates CLPXP-mediated degradation of ALAS, elucidating the mechanism of heme-induced feedback regulation in heme biosynthesis.
bioRxiv · Jul 5, 2024 · PreprintBiochemistry