Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation
T. E. Condos, K. M. Dunkerley, E. A. Freeman, K. Barber, J. Aguirre, V. Chaugule, Y. Xiao, L. Konermann, H. Walden, G. S. Shaw
This study reveals how phosphorylation and ubiquitin binding synergistically activate parkin by reorganizing its structure to facilitate ubiquitin transfer.
bioRxiv · Jun 12, 2018Biochemistry