Y. Xiao

Receptor-guided engineering of oncolytic vaccinia creates a synthetic support niche for off-the-shelf NK cell therapy

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Establishing the foundations for a data-centric AI approach for virtual drug screening through a systematic assessment of the properties of chemical data

This paper demonstrates that conventional ML can achieve high accuracy in virtual screening with proper data and representation, outperforming deep learning methods.

Differential seasonal effects of ephemeral legumes in response to moisture-nitrogen coupling in the deserts of northwestern China

This study examines how moisture and nitrogen affect two desert legumes, showing growth and chlorophyll differences under varying treatments, with moisture-nitrogen coupling influencing physiological responses.

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.

Photo-Uncaging Triggers on Self-Blinking to Control Single-Molecule Fluorescence Kinetics for Super-Resolution Imaging

The paper develops a new fluorophore, NOSR, that enables controlled single-molecule blinking for improved super-resolution imaging of microtubules and mitochondrial outer membranes.

ATM-Mediated Translocation of RanBPM Regulates DNA Damage Response by Stabilizing p21 in Non-Small Cell Lung Cancer Cells

The paper identifies a novel mechanism where RanBPM stabilizes p21 via deubiquitination, regulating DNA damage response in NSCLC cells.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohns disease associated adherent-invasive Escherichia coli infection

The paper identifies novel therapeutic targets for AIEC infection by stratifying macrophages based on bacterial load and showing that targeting these pathways reduces AIEC replication.

Armed Macrophages as Hunters for Photodynamic Therapy of Systemic Bacterial Infections by Bathing in the Sunshine

This paper introduces a 'live drug' called A-RAWs that uses sunlight to treat systemic bacterial infections by capturing bacteria and killing them with photodynamic therapy upon reaching the skin.

Mutation of OsCDS5 confers broad-spectrum disease resistance in rice

This study shows that mutating OsCDS5 in rice enhances resistance to multiple diseases by increasing ROS production and defense gene expression.

In situ structural determination of cyanobacterial phycobilisome-PSII supercomplex by STAgSPA strategy

The paper develops a method called STAgSPA to determine the in situ structure of a cyanobacterial PBS-PSII supercomplex at 3.5 Å resolution, revealing energy transfer mechanisms and structural coupling.

Perception of Motion Salience Shapes the Emergence of Collective Motions

The paper investigates collective motion patterns in bird flocks and develops a model based on motion salience to explain hierarchy formation and swarm behavior.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

High-sensitivity whole-genome recovery of single viral species in environmental samples

This paper develops a method to recover complete viral genomes from environmental samples with high sensitivity, achieving 100% recovery of a spiked-in virus and 99.4% for a larger virus.

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells.

This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.

Large-scale phenotypic and genomic characterization of Listeria monocytogenes susceptibility to quaternary ammonium compounds

This study characterizes QAC susceptibility in 1,671 L. monocytogenes isolates, identifies genetic markers linked to tolerance, and examines global prevalence across 37,897 genomes.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

This study develops nanoPDLIM2, a PDLIM2-expressing nanoparticle, which enhances PD-1 blockade and chemotherapy efficacy in lung cancer by reactivating tumor immunity and reducing drug resistance.

Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system

The paper determines cryo-EM structures of SPARTA in different states to elucidate its auto-inhibition and activation mechanisms.

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

SARS-CoV-2 Nsp1 regulates translation start site fidelity to promote infection

This study identifies Nsp1's role in enhancing SARS-CoV-2 translation by interacting with EIF1A, leading to reduced viral titers when EIF1A is depleted.

Evolution of Shewanella oneidensis MR-1 in competition with Citrobacter freundii

This study examines how Shewanella oneidensis MR-1 evolves in competition with Citrobacter freundii An1 under different electron acceptor conditions.

Functional glycoproteomics by integrated network assembly and partitioning

This paper introduces a systems-level approach to study O-GlcNAcylation by integrating AP-MS and chemoproteomics with network analysis, revealing both conserved and tissue-specific functions.

A population-averaged structural connectomic brain atlas of 422 HCP-Aging subjects

This paper creates a population-averaged structural connectomic brain atlas from 422 HCP-Aging subjects to provide anatomical and structural connectivity information for neurosurgical planning and neurodegenerative research.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

This paper develops an in vitro method using human plasma-like medium to study glioma metabolism and immune interactions, revealing microenvironment-dependent metabolic features and immune responses.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.