Fitness landscape analysis of a tRNA gene reveals that the wild type allele is sub-optimal, yet mutationally robust
T. Gabzi, Y. T. Pilpel, T. Friedlander
The paper analyzes a yeast tRNA gene fitness landscape, finding the wild type is sub-optimal and mutationally robust, while fitter variants are mutationally fragile.
bioRxiv · Sep 27, 2021Evolutionary Biology