Skeletal muscle aging drives sex- and compartment-specific protein insolubility that is modifiable by proteostasis-directed treatments
P. H. C. Mesquita, T. Goyal, X. Ren, J. Papinska, M. E. Taylor, T. J. Lundgren, Z. R. Hettinger, Benjamin F. Miller
This study investigates age-related changes in protein insolubility in skeletal muscle and shows that these changes are sex- and compartment-specific and can be modified by exercise and rapamycin.
bioRxiv · Nov 9, 2026 · PreprintPhysiology