Benjamin F. Miller

This study investigates age-related changes in protein insolubility in skeletal muscle and shows that these changes are sex- and compartment-specific and can be modified by exercise and rapamycin.

This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.

This study shows that ULK1 and ULK2 regulate skeletal muscle growth by balancing protein synthesis and degradation, with lifelong deficiency causing hypertrophy but reduced muscle quality and function, while short-term deficiency allows hypertrophy without impairment.

The paper shows that transient MYC activation in skeletal muscle mimics exercise-induced adaptations, leading to hypertrophy, metabolic changes, and fiber type shifts.

This study shows that overactive PDGFRα and PDGFRβ signaling in mice leads to distinct but overlapping fibrotic and growth-related muscle changes, with sex-specific effects.

This study identifies TIMM17A as a key mediator of HSF1-driven mitochondrial biogenesis and function in cancer cells, revealing a mechanism linking HSF1 to mitochondrial protein import and energy production.

This study uses in vivo 2-photon imaging and photoactivatable fluorescent labeling to show that mitochondrial dynamics in skeletal muscle are slower in vivo than previously thought, with age-related differences and exercise-induced increases.

This study shows that hyperactive mTORC1/4EBP1 signaling accelerates cardiac aging by dysregulating proteostasis in mice.

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.

The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.