T. Gutsmann

Cytoadhesion of Plasmodium falciparum-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells

The paper shows that Plasmodium falciparum-infected red blood cells alter gene expression in brain endothelial cells, activating immune and antiviral pathways, and increasing cytokine and angiogenesis-related genes.

Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophosholipase A PlaA

This study reveals the structural basis for the regulated activation and substrate preference of PlaA, a lysophospholipase in Legionella pneumophila, showing how disulfide loop cleavage enhances catalytic activity and substrate specificity.